hla-drb1, dqa1 and dqb1 alleles and hap-lotypes frequencies in iranian healthy adult responders and non-responders to recombi-nant hepatitis b vaccine

Authors

ali akbar amirzargar

national cell bank of iran, pasteur institute of iran, tehran, iran nilufar mohseni

national cell bank of iran, pasteur institute of iran, tehran, iran mohammad ali shokrgozar

national cell bank of iran, pasteur institute of iran, tehran, iran zohreh arjang

national cell bank of iran, pasteur institute of iran, tehran, iran nahid ahmadi

abstract

background: different studies have demonstrated that a small proportion of healthy individuals receiving the hepatitis b (hb) vaccine do not produce protective levels of anti-hb antibody, a phenomenon which could be linked to certain human leukocyte an-tigen (hla) class-ii alleles or haplotypes. objectives: the present study was under-taken to determine the frequency of hla class-ii alleles in iranian healthy adult re-sponders and non-responders to hb vaccine. methods: twelve non-responders (anti-hbs antibody100 iu/l) were tissue typed for hla class-ii. hla-drb1, dqb1 and dqa1 alleles were determined using polymerase chain reaction based on sequence specific primers (pcr-ssp) technique. accessibility to excess amount of genomic dna was possible using epstein-barr virus (ebv)-transformed b-cells established from all vaccinees. results: our results demon-strated increased frequencies of hla- drb1*07, drb1*03, drb1*04, dqb1*0201, dqa1*0201 alleles and hla- drb1*07/dqb1*0201/dqa1*0201 and drb1*04/dqb1*0302/dqa1*03011 haplotypes in the non-responder group. com-parison between responders and non-responders revealed only a significant difference for dqb1*0201 allele (p

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Journal title:
iranian journal of immunology

جلد ۵، شماره ۲، صفحات ۹۲-۹۹

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